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Atypical fibrous histiocytoma and atypical fibroxanthoma: presentation of two cases. Kram A, Stańczyk J, Woyke S Pol J Pathol 2003;54(4):267-71. PMID: 14998296

However, since inception, it has been the source of controversy. Despite being markedly pleomorphic, metastases occur in less than 1 percent of cases, with the majority preceded by tumor recurrence [ 1 , 2 , 3 ]. Atypical fibroxanthomas might be detected as a nodular skin lesion of some millimetres up to some centimetres on ultrasound, CT or MRI. After administration of a contrast agent, it has been described to show enhancement. Treatment and prognosis. Atypical fibroxanthomas are surgically removed and have a good prognosis. Atypical fibroxanthoma usually stains for CD10 and is negative for the markers of cutaneous squamous cell carcinoma, melanoma, angiosarcoma and leiomyosarcoma.

Atypical fibroxanthoma prognosis

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Atypical fibroxanthoma (AFX) usually arises in sun-exposed skin of the head and   Nov 17, 2019 from atypical fibroxanthoma (b); (c) In Merkel cell carcinoma, p63 expression is correlated with poor prognosis. The Kaplan–Meier plot shows  May 30, 2019 Keywords: Cutaneous sarcomas; Atypical fibroxanthoma;. Dermal pleomorphic sarcoma; Surgery. *Correspondence: Uwe Wollina.

Atypical fibroxanthomas might be detected as a nodular skin lesion of some millimetres up to some centimetres on ultrasound, CT or MRI. After administration of a contrast agent, it has been described to show enhancement. Treatment and prognosis. Atypical fibroxanthomas are surgically removed and have a good prognosis.

An atypical fibroxanthoma is a rare, malignant fibrohistiocytic neoplasm, which develops most commonly on the sun-exposed skin of elderly individuals. It has invasive potential, may recur locally after excision, and very rarely metastasizes.

Atypical fibroxanthoma prognosis

Jul 29, 2020 Atypical fibroxanthoma (AFX) is a rare, low-grade sarcoma that most often occurs on sun-exposed skin AFX carries a good prognosis overall.

Atypical fibroxanthoma prognosis

Despite the high-grade morphologic features, atypical fibroxanthoma is an indolent lesion with excellent prognosis. Local excision usually is curative. Aug 17, 2020 As PDS exhibit a less favorable prognosis than squamous Mentzel T, Requena L, Brenn T. Atypical Fibroxanthoma Revisited. Surg Pathol  Nov 8, 2018 Atypical fibroxanthoma is considered to be the superficial variant of CPS, as they are histologically indistinguishable and have been shown to  Nov 17, 2019 from atypical fibroxanthoma (b); (c) In Merkel cell carcinoma, p63 expression is correlated with poor prognosis. The Kaplan–Meier plot shows  May 30, 2019 Keywords: Cutaneous sarcomas; Atypical fibroxanthoma;. Dermal pleomorphic sarcoma; Surgery.

Atypical fibroxanthoma prognosis

Pathology. 1975(3); 7:173-7.
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Despite its highly atypical histological appearance it is almost always associated with innocuous clinical behaviour.

Exposure to ultraviolet light most likely contributes to the development of AFX. Atypical fibroxanthoma (AFX) is an ultraviolet radiation-associated dermal neoplasm. To address the clinicopathologic and molecular features of this particular neoplasm. The author conducted a literature review using PubMed searching for articles relating to AFX. AFX usually appears as a rapidly growing nodular or nodulo-ulcerative lesion.
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Mar 16, 2021 Skin nonmelanocytic tumor - Atypical fibroxanthoma (AFX), Rare, low grade, malignant cutaneous tumor of uncertain differentiation, first 

AFX most commonly occurs on sun-exposed skin in elderly individuals. Background: Atypical fibroxanthoma (AFX) is an uncommon, rapidly growing cutaneous neoplasm of uncertain histogenesis. Thus far, there are no guidelines for diagnosis and therapy of this tumor.


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Atypical Fibroxanthoma. Atypical fibroxanthoma is a malignant skin tumor with histologic features similar to those of undifferentiated pleomorphic sarcoma, but lacking its more aggressive behavior. The tumor is composed of pleomorphic cells with hyperchromatic nuclei and abundant cytoplasm, commonly arranged in a spindle c ….

Recurrence and metastasis are more likely in people that are immunosuppressed. Fortunately, atypical fibroxanthoma rarely metastasizes and recurs in only 6% to 10% of cases 6).